Alkaloid Encyclopedia

The most abundant alkaloid in kratom. A partial mu-opioid agonist responsible for the plant's core analgesic and stimulant properties at different doses.

The second-most abundant kratom alkaloid. A smooth muscle relaxant with limited opioid receptor activity.

A diastereomer of mitragynine found in moderate amounts. Acts as a smooth muscle relaxant.

Typically the third most abundant kratom alkaloid. Acts as an antagonist at mu-opioid receptors.

A potent mu-opioid agonist present in trace amounts. Despite low concentration it contributes significantly to kratom's analgesic effects.

A minor oxindole alkaloid that inhibits acetylcholinesterase, a mechanism similar to some Alzheimer's medications.