Medical Disclaimer
Educational purposes only. Not medical advice. Consult a healthcare provider before combining any substances. This tool summarizes published research — it does not replace clinical judgment. If you are experiencing a medical emergency, call 911.
Drug Interaction Checker
Known interactions between kratom alkaloids and other substances. Every entry is sourced from peer-reviewed literature. 3 major and 0 moderate interactions documented.
Benzodiazepines
Also: alprazolam, Xanax, diazepam, Valium, lorazepam, Ativan…
Combining kratom with benzodiazepines significantly increases the risk of excessive sedation, respiratory depression, and loss of consciousness.
Recommended Action
Avoid combining.
Full Opioid Agonists
Also: morphine, oxycodone, fentanyl, heroin
Combining kratom with full opioid agonists creates dangerous additive respiratory depression.
Recommended Action
Avoid combining.
Alcohol
Also: ethanol, beer, wine, spirits
Alcohol and kratom together significantly increase sedation, impair motor coordination, and raise the risk of respiratory depression.
Recommended Action
Avoid combining.
This database covers known kratom–drug interactions from published research. Absence of a listing does not guarantee safety. Always disclose all substance use to your healthcare provider.