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MGM-16

MGM-16 · CAS n/a

Synthetic analog

Formula

C₂₄H₃₂N₂O₅

Molecular Weight

428.53 g/mol

Abundance in Leaf

Synthetic

Last Reviewed

2026-03-12

What Is MGM-16?

MGM-16 is a structural isomer of MGM-15 with enhanced metabolic stability. It is a partial agonist at the mu-opioid receptor with high affinity (Ki ~12 nM) and strong G-protein bias. Beta-arrestin-2 recruitment is moderate at supratherapeutic concentrations but minimal at analgesic doses, and a ceiling effect is observed at higher doses. Like MGM-15, it is a synthetic tool compound used in pharmacological research and is not found in kratom or consumer products.

Dose-Dependent Effects

Receptor Activity

Receptor	Ki (nM)	Activity Type	What This Means
Mu-opioid (MOR)	~12	Partial agonist (G-protein biased)	High-affinity MOR partial agonist with strong G-protein bias. Ceiling effect observed at higher doses.
Delta-opioid (DOR)	~180	Moderate affinity	Moderate binding at delta-opioid receptors, unlike most other mitragynine analogs.

Safety & Adverse Effects

Research status

MGM-16 is a synthetic research compound. All pharmacological data is preclinical. Not present in any consumer product.

Source: Váradi et al. 2016

Drug Interactions

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COA Connection

Appears on Certificates of Analysis as: N/A. Graded under Not measured on COAs (Synthetic research compound).

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Cited Literature

[1]

Váradi A, Marrone GF, Palmer TC, et al. (2016). Mitragynine/corynantheidine pseudoindoxyls as opioid analgesics with mu agonism and delta antagonism, which do not recruit β-arrestin-2. J Am Chem Soc.

DOI: 10.1021/jacs.6b00360

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