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SR-17018

SR-17018 · CAS n/a

Non-indole synthetic

Formula

C₂₁H₂₂FN₃O₃

Molecular Weight

383.42 g/mol

Abundance in Leaf

Synthetic

Last Reviewed

2026-03-12

What Is SR-17018?

SR-17018 is a non-indole-based mu-opioid receptor agonist structurally distinct from the mitragynine class. It was designed as a tool compound to study G-protein-biased signalling and is one of the most biased MOR agonists in published literature, showing over 100-fold preference for G-protein activation over beta-arrestin recruitment. However, some studies suggest this bias may be assay-dependent. SR-17018 is not derived from kratom and is not found in any consumer product.

Dose-Dependent Effects

Receptor Activity

Receptor	Ki (nM)	Activity Type	What This Means
Mu-opioid (MOR)	~8.5	Agonist (extreme G-protein bias)	High-affinity MOR agonist with >100x G-protein preference over beta-arrestin. Bias magnitude may vary by assay system.

Safety & Adverse Effects

Research status

SR-17018 is a synthetic research tool compound not derived from kratom. All data is preclinical. Not present in any consumer product.

Source: Schmid et al. 2017

Drug Interactions

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COA Connection

Appears on Certificates of Analysis as: N/A. Graded under Not measured on COAs (Synthetic research compound).

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Cited Literature

[1]

Schmid CL, Kennedy NM, Ross NC, et al. (2017). Bias factor and therapeutic window correlate to predict safer opioid analgesics. Cell.

DOI: 10.1016/j.cell.2017.10.035

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